Expression of oncogenic KrasG12D initiates lung adenomas in a mitogen-activated protein kinase (MAPK) signal-dependent manner from only a subset of cell types in the adult mouse lung.Amplification of MAPK signaling is associated with progression to malignant adenocarcinomas, but hanes 42tb whether this is a cause or a consequence of disease progres
Spondylocostal dysostosis is a congenital disorder of the axial skeleton documented in human families from diverse racial backgrounds.The condition is characterised by truncal shortening, extensive hemivertebrae and rib anomalies including malalignment, fusion and reduction in number.Mutations in the Notch signalling pathway genes DLL3, MESP2, LFNG
Directional ionogram and F-region drift observations were conducted at seven digisonde stations in South America during the COPEX campaign from October to December 2002.Five stations in Brazil, one where can i buy walnettos candy in Argentina, and one in Peru, monitored the ionosphere across the continent to study the onset and development of F-reg
The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years.In order to increase the drugability of these frequently unstable and rapidly cleared molecules, chemical modifications are of great interest.Automated solid-phase peptide syn
Introduction In sub-Saharan Africa (SSA), Human Immunodeficiency Virus (HIV) is the leading cause of morbidity and mortality.Community healthcare workers (CHWs) worldwide have been reported to be effective in strengthening the HIV programme by providing services such as adherence support, HIV education and safe sex education as part of their roles.